Dr.Gergana Nestorova Louisiana Tech University research lab
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  • About
  • LAB MEMBERS
  • Projects
  • Publications
  • Courses

The Applied Genomics and Biotechnology Lab

PUBLICATIONS

  • K. H. Hutson, K. Willis, C.D. Nwokwu, M. Maynard, G.G. Nestorova,  Photon versus proton neurotoxicity: Impact on mitochondrial function and 8-OHdG base-excision repair mechanism in human astrocytes. Neurotoxicology, 82, 158-166 (2021). 
  • S. M. I. Bari, L. G. Reis, and G. G. Nestorova, Numerical optimization of key design parameters of a thermoelectric microfluidic sensor for ultrasensitive detection of biochemical analytes. ASME Journal of Thermal Sciences and Engineering Applications. 13(2), 021024 (2020). ​
  • S. M. I. Bari, L. Reis, and G. G. Nestorova, Calorimetric sandwich-type immunosensor for quantification of TNF-α. Biosensors and Bioelectronics, 126, 82-87 (2019).
  • G. G. Nestorova, K. Hasenstein, N. Nguyen, M. A. DeCoster, and N.D.  Crews, N., Lab-on-a-chip mRNA purification and reverse transcription via a solid-phase gene extraction technique, Lab on a chip, 17(6), 1128-1136 (2017). 
  • G. G. Nestorova, B. S. Adapa, V.L. Kopparthy and E. J. Guilbeau. Lab on a Chip Label-free DNA Biosensor for Detection of Nucleic Acid Sequence. Sensors and Actuators B: Chemicals 225, 174-180, (2016). 
  • G. G. Nestorova, N. D. Crews, and E. J. Guilbeau. Theoretical and experimental analysis of thermoelectric lab-on-a-chip ELISA, Microfluidics and Nanofluidics, 1-10(2015).  
  • G. G. Nestorova, V.L. Kopparthy, N. D. Crews, and E.J.  Guilbeau. Thermoelectric lab-on-a-chip ELISA, Analytical Methods 7, 2055 – 2063 (2015).  
  • L. Shi, E. J. Guilbeau, G. G. Nestorova, and W. Dai. A mathematical model and numerical method for thermoelectric DNA sequencing. Heat and Mass Transfer, 50(5), 1–17 (2014). 
  • C. Zhang, G. G. Nestorova, R. A. Rissman, and J. Feng, Detection and quantification of 8hydroxy-2′-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis, Electrophoresis, 34 (15), 2268–2274 (2013). 
  • V. L. Kopparthy, S. M. Tangutooru, G. G. Nestorova, and E. J. Guilbeau, Thermoelectric microfluidic sensor for bio-chemical applications, Sensors and Actuators B: Chemical 166, 608– 615 (2012). 
  • S. M. Tangutooru, V. L. Kopparthy, G. G. Nestorova, and E.J. Guilbeau., Dynamic thermoelectric glucose sensing with layer-by-layer glucose oxidase immobilization, Sensors and Actuators B: Chemical 166, 636–641 (2012). 
  • G. G. Nestorova, and E. J. Guilbeau, Thermoelectric Method for Sequencing DNA, Lab on a Chip 11 (10), 1761–1769 (2011). 
  • S. M. Tangutooru, V. L. Kopparthy, R. Gumma, G. G. Nestorova, and E. J. Guilbeau, Dynamic Thermoelectric Microfluidic Glucose Sensing with layer-by-layer Glucose Oxidase Immobilization”, International Journal of Medical Implants and Devices 5 (2), 66 (2011). 
  • J. Walley, D. Kelley, G. G. Nestorova, D. Hirschberg, and K. Dehesh, Arabidopsis deadenylases AtCAF1a and AtCAF1b play overlapping and distinct roles in mediating environmental stress responses, Journal of Plant Physiology 152 (2), 866–875 (2010).  
  • K. D. Wilson, Z. Li, R. Wagner, P. Yue, P. Tsao, G. G. Nestorova, M. Huang, D. Hirschberg, P. Yock, T. Quartermoust, and J. Wu, Transcriptome Alteration in the Diabetic Heart by Rosiglitazone: Implications for Cardiovascular Mortality, PLoS ONE, 3(7), (2008).  

BOOK CHAPTERS

  •   1.  G.G. Nestorova. Thermoelectric lab-on-a-chip technologies:design, applications, challenges, and future trends, Advance in Engineering Research (19), Ed. V. Petrova, Publisher: Nova Science Publishers, Inc., (2017).

CONFERENCE PRESENTATIONS

  • C. D. Nwokwu,S.M. I. Bari, G. G. Nestorova, Lab-on-a-chip platform for cell co-culture and purification of exosomes,     Innovations in Microfluidics 2020, Boston, MA
  • C. D. Nwokwu, S. M. I. Bari, G. G. Nestorova, ‘Smart’ microprobes imbued with recognition element as a sensitive bioanalysis platform for exosomes, 94th Louisiana Academy of Science Meeting, Alexandria, LA, 2020.   
  • K. H. Hutson, K. Willis, C. D. Nwokwu, G. G. Nestorova, Ionizing radiation-induced alteration of mitochondrial copy number and base-excision repair capabilities in human astrocytes, 94th Louisiana Academy of Science Meeting, Alexandria, LA, 2020. 
  • S. M. I. Bari, L. G. Reis, G. G. Nestorova, Calorimetric sandwich-type immunosensor for quantifying TNF-α: experimental results and numerical analyses of heat transfer for maximized detection sensitivity, 94th Louisiana Academy of Science Meeting, Alexandria, LA, 2020.
  • N. D. Crews and G. G. Nestorova, One-step gene extraction tool, 2019 Payload Operations Integration Working Group meeting, Huntsville, AL. 
  • D. Gaines, R. Ledbetter, N.D. Crews, G.G. Nestorova, One-step nucleic acid sampling technology for genetic analysis on the International Space Station, 2019 Space Summit, Coronado, CA.
  •  S. M. I. Bari, L. G. Reis, G. G. Nestorova, Microfluidic calorimetric immunosensor: experimental results and COMSOL simulations of heat transfer in microchannel, APS 2019 March Meeting, Boston, MA.
  •  C. D. Nwokwu, S. M. I. Bari, G. G. Nestorova, Platform for Solid-Phase and Antigen-Specific Purification of   Exosomes, 35th Southern Biomedical Engineering Conference (SBEC), Hattiesburg,MS, 2019. 
  •  S. M. I. Bari, L. G. Reis, G. G. Nestorova, Lab-on-a-chip thermoelectric immunoassay for detection of TNF-α: experimental results and COMSOL simulations of heat transfer, 35th Southern Biomedical Engineering Conference   (SBEC), Hattiesburg,MS, 2019. 
  •  K. H. Hutson, C. D. Nwokwu, K. M. Willis, C. Vazquez, K. H. Hutson, G. G. Nestorova, Identification of miRNA-OGG1   mRNA interactions: small RNA sequencing and immunoprecipitation analysis, LaSPACE Council Fall Meeting, Shreveport, LA, 2018. 
  • K. M. Willis, C. D. Nwokwu, K. H. Hutson, G. G. Nestorova, Effect of high-energy radiation on mitochondrial DNA copy   number changes and 8OHdG levels in human astrocytes, LaSPACE Council Fall Meeting, Shreveport, LA, 2018. 
  •  S. M. Bari, G.G. Nestorova, Lab-on-a-chip immunoassay for thermoelectric quantification of TNF-α, 34th Southern Biomedical Engineering Conference (SBEC) MAS 2018; 63:132, suppl.1.Presenting author. 
  •  K. H. Hutson, K. M. Willis, A. Y. Xiao, L. Harrison, G. G. Nestorova, Identification of novel miroRNAs that regulate    OGG1 mediated DNA repair, LaSPACE Council Fall Meeting, Baton Rouge, LA, 2017
  •  S. M. Bari, G. G. Nestorova, Lab-on-a-chip thermoelectric ELISA for detection of TNF-α, Industry Day Conference Shreveport, LA, 2017.
  •  K. H. Hutson, K. M. Willis, A. Y. Xiao, L. Harrison, G. G. Nestorova, Identification of novel miroRNAs that regulate  OGG1 mediated DNA repair, Industry day conference, Shreveport, LA, 2017.
  •  K. Willis, G.G. Nestorova, OGG1 role in oxidative stress induced DNA damage and repair, 2017 ANS Research  Symposium, Louisiana Tech University, LA, 2017.
  •  T. Pham, M. Hamideh, K. Willis, and G. G. Nestorova, Lab-on-a-chip thermoelectric ELISA technology for quantitation    of TNF-α, 2017 ANS Research Symposium, Louisiana Tech University, LA.
  •  G.G. Nestorova, K. Hasenstein, and N.D. Crews, Lab-on-a-chip-meditated RNA extraction via steel solid phase gene  extraction probes, LaSPACE Council Fall Meeting, Ruston, LA, 2016.​ 
  • G.G. Nestorova, K. Hasenstein, N. Nguyen, M. DeCoster, N. D. Crews. Lab-on-a-chip meditated RNA purification   from  3D cell spheroids via solid-phase gene extraction technique, 2016 ASME Meeting, Washington, DC, 2016. 
  • ​ D. Jana, D. Saint Jean, S. Abdurakhimov, V. Kopparthy, G.G. Nestorova, N. Pal, N. Nguyen, P. Derosa, L. Sawyer, N. Crews, and M. DeCoster, Genetic Assessment of the Space Environment using MEMS Technologies, 2016 APS March  meeting, Baltimore, MD, 2016.
  •  G.G. Nestorova, K. Hasenstein, and N.D. Crews, Lab-on-a-chip-meditated RNA extraction via steel solid phase gene extraction probes, Industry day, LSUHS-Shreveport, LA, 2015.
  •  G.G. Nestorova, N.D .Crews, and E.J. Guilbeau, Mathematical Simulations of Heat transfer and Fluid Dynamics in a       Microfluidc Calorimeter with Integrated Thin-film Thermopiles, 2014 Annual Fall Meeting of the BMES, San Antonio,     TX, 2014.
  •  G.G. Nestorova, V.L. Kopparthy, S.M. Tangutooru, R. Gumma, and E.J. Guilbeau, Effect of Hydrodynamic Focusing on   Increased Sensitivity of Thermoelectric Method for DNA Sequencing, 2011 Annual Fall Meeting of the BMES, Hartford,   CT, 2011.
  •   V.L. Kopparthy, S.M. Tangutooru, R. Gumma, G.G.  Nestorova, and E.J. Guilbeau, Highly Sensitive Continuous Flow      Micro-calorimeter for Biological Applications, 2011 Annual Fall Meeting of the BMES, Hartford, CT, 2011.
  •  G.G. Nestorova, V.L. Kopparthy, S.M. Tangutooru, R. Gumma, and E.J. Guilbeau, Thermoelectric method for     sequencing by synthesis, Lab-on-a-chip World Congress, San Francisco, CA, 2011.
  •  G.G. Nestorova, V.L. Kopparthy, S.M. Tangutooru, R. Gumma, and E.J. Guilbeau, Thermoelectric method for sequencing by synthesis, Louisiana Academy of Science 85th Annual Meeting, Monroe, LA, 2011.
  •  S.M. Tangutooru, R. Gumma, V.L. Kopparthy, G.G. Nestorova, and E.J. Guilbeau, Fabrication and Characterization  Highly Sensitive Thin-Film Thermopiles, Louisiana Academy of Science 85th Annual Meeting, Monroe, LA (2011).
  •  S.M. Tangutooru, V.L. Kopparthy, R. Gumma, G.G. Nestorova, E.J. Guilbeau,  Dynamic Thermoelectric Glucos sensing with Layer-by-layer Glucose Oxidase Immobilization, SBEC 27th Annual Meeting. Arlington, TX, 2011.
  •  J. Feng, C. Zhang, S. Wang ,  H. Xia H,  B. Hollins,  G. Chen,  J. Spaulding , M.  Circu , C. Rodriguez, G.G. Nestorova,  M. Decoster, K. Murray, S. Soper, and T.Y. Aw, Monitoring Protein Oxidative damage in aging and Alzheimer’s disease, LBRN 9th Annual Meeting, Shreveport, LA, 2011.
  •  V.L. Kopparthy, S.M. Tangutooru, R. Gumma, G.G. Nestorova, and E.J. Guilbeau, Characterization of Microfluidic    calorimeter for measuring small dynamic temperature changes, 2010 BMES Annual meeting, Austin, TX, 2010.
  •  G.G. Nestorova, C.  Zhang, and J. Feng, Quantitive determination of 8OHdG in Alzheimer transgenic mice urine using  capillary electrophoresis with laser induced fluorescence detection, SFRBM 17th Annual Meeting, Orlando, FL, 2010. 

PATENTS AND INTELLECTUAL PROPERTY DISCLOSURE

  • G. G. Nestorova, “Thermoelectric ELISA Method for Detection of Nucleic Acid, RNA, and Bacteria Cells”, provisional patent, serial number 62/268, 941, filed 12/17/15 by Louisiana Tech University. 
  • G. G. Nestorova, “Thermoelectric ELISA Method for Detection of Nucleic Acid, RNA, and Bacteria Cells”, Report of Invention #2015-05 filed with Louisiana Tech University Office of Intellectual Property and Commercialization May 2015.  
  • G. G. Nestorova, “Thermoelectric Method for Performing ELISA”, provisional patent, serial number 62/107,613, filed 1/26/15 by Louisiana Tech University
  • G. G. Nestorova,  “Thermoelectric Method for Performing ELISA”, Report of invention #2013-19 filed with Louisiana Tech Uniuversity Office of Intellectual Property and Commercialization December 2013.


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